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It will depend on the ability to connect multiple sources of evidence, including: Clinical trial data Real-world clinical data Patient-reported outcomes Biomarker and genomic information Healthcare utilization data Digital health technologies The goal is not to replace randomized clinical trials but to complement them, creating a more complete picture of how therapies perform in real-world healthcare settings
Planta 202(3):357369
Genomic integrity The active maintenance of all the genetic elements in the cells of an organism (including DNA, RNA and epigenetic determinants and appropriate developmental gene expression) for proper dynamic function
Martello E, Perondi F, Bisanzio D, Lippi I, Meineri G, Gabriele V
Functional targeting of cancer-associated fibroblasts (CAFs) using a combination of DFO and follistatin-like protein 1 (FSTL1) -neutralizing antibody significantly alleviated CAF-induced natural killer cell (NK cell) ferroptosis and boosted the cytotoxicity of NK cells against GC [104]
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